Set Safari Homepage
Description
This profile changes the Safari Homepage for the currently logged in user.
This recipe was tested on 10.13.2 with Safari 11.0.2
Ingredients
Directions
Preference Domain : com.apple.safari
Key: HomePage
Type: String
Value: https://www.filewave.com

3. Close the Profile Editor
4. Double click on the newly created profile → select the settings tab → uncheck the box for "Users" under installation and check the box for "System" under installation.

5. Then deploy the profile out to your selected macOS devices.
Notes
Some additional options that may require consideration:
Additional keys
Key: LastSafariVersionWithWelcomePage-v2Type: StringValue: 9.0(Description: Show Safari Welcome Page to new users. String set as last version of Safari welcome page was shown; may require changing with newer versions of Safari)Key: NewWindowBehaviorType: NumberValue: 0(Description: Policy for new window contents. 0 = show homepage\, 1 = show empty page\, 2 = show same page as current window/tab\, 3 = show bookmarks)Key: NewTabBehaviorType: NumberValue: 0(Description: Policy for new tab contents. 0 = show homepage\, 1 = show empty page\, 2 = show same page as current window/tab\, 3 = show bookmarks)